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This widespread application without any evidence of its effectiveness provided the underpinning of the PROMISE trial. The PROMISE trial randomized these women between progesterone or placebo (Coomarasamy et al. The paradox however is that these trials, which are the most urgent ones to do, are also the ones for which recruitment of patients is the most difficult, especially if the interventions we want to debunk have been applied by the majority of clinicians and for a long period of time. It is then difficult for many to realize and to accept that what is regarded as common practice is based on hardly anything. As a consequence, patients experience randomization as decreasing their chances of success. Decent counseling of patients by dedicated doctors is of utmost importance in these trials. Since our basic reasoning rests heavily Trienolone the biological plausibility behind the effect of an intervention, Trenbolone Enanthate, we feel the need to add a few remarks on the role of biologic plausibility. First, we have framed our description of anadrol for sale
">what typifies biologic plausibility in the setting of scientific medicine, in Trenbolone Acetate biological hypotheses are generated and after thorough fundamental research rejected or not. It follows that types of medicine that do not fulfill these criteria are not part of scientific medicine. An example of this is acupuncture. The mechanisms behind the effect of acupuncture are based on the so-called chi and body meridians, of which existence there is no scientific evidence (Kaptchuk, 2002). Second, researchers may be so convinced of their own beliefs and reasoning that they shift from uncertain biologic plausibility to known biologic plausibility, even when scientific data underpinning this shift are absent.

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